Not Sure What To Buy? Download Our One Page CBD Guide

The Benefits of Using CBD for Chronic Fatigue

Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex disorder characterised by extreme fatigue that doesn’t improve with rest and can worsen with physical or mental activity. The exact cause of CFS is unknown, and its symptoms can vary widely, making it challenging to diagnose and treat. As traditional treatment options often fall short, many individuals are exploring alternative therapies, including the use of cannabidiol (CBD). This blog post delves into the potential benefits of using CBD for chronic fatigue, supported by research links and scientific evidence.

Understanding Chronic Fatigue Syndrome

Chronic Fatigue Syndrome affects millions of people worldwide. Symptoms include:

  • Severe fatigue
  • Sleep disturbances
  • Cognitive difficulties
  • Muscle and joint pain
  • Headaches
  • Sore throat and swollen lymph nodes

The debilitating nature of CFS can significantly impact an individual’s quality of life. Traditional treatments often focus on symptom management through medications, cognitive behavioral therapy (CBT), and graded exercise therapy (GET). However, these treatments do not work for everyone, and some patients seek alternative solutions.

What is CBD?

CBD, or cannabidiol, is a naturally occurring compound found in the cannabis plant. Unlike THC (tetrahydrocannabinol), another well-known compound from cannabis, CBD does not have psychoactive effects, meaning it doesn’t produce a “high.” CBD has gained popularity for its potential therapeutic benefits, including anti-inflammatory, analgesic, and anxiolytic properties.

How CBD May Help with Chronic Fatigue

1. Pain Relief

Many CFS patients suffer from chronic pain, including muscle and joint pain. CBD has been shown to have analgesic properties that could help alleviate pain. A study published in the Journal of Experimental Medicine suggests that CBD can significantly reduce chronic inflammation and pain by targeting specific receptors in the endocannabinoid system (ECS) .

2. Improving Sleep Quality

Sleep disturbances are a common symptom of CFS. CBD may help improve sleep quality by addressing some of the underlying issues that disrupt sleep. Research published in the Permanente Journal indicates that CBD could reduce anxiety and improve sleep in a large case series of 72 adults with anxiety and sleep concerns .

3. Reducing Anxiety and Depression

Mental health issues, such as anxiety and depression, are prevalent among CFS patients. CBD has been found to have anxiolytic and antidepressant effects. A review published in the Neurotherapeutics Journal highlights the potential of CBD as a treatment for anxiety disorders due to its interaction with serotonin receptors .

4. Boosting Energy Levels

While more research is needed, some studies suggest that CBD could help boost energy levels. CBD’s interaction with the ECS may help regulate functions like mood, sleep, and appetite, potentially leading to an overall increase in energy and reduction in fatigue.

5. Anti-Inflammatory Effects

Inflammation is believed to play a role in the pathogenesis of CFS. CBD is known for its potent anti-inflammatory properties. Research from the European Journal of Pain demonstrates that CBD can help reduce inflammation and pain in animal models of arthritis .

6. Neuroprotective Properties

Cognitive difficulties, often referred to as “brain fog,” are a significant symptom of CFS. CBD has shown neuroprotective properties that could help improve cognitive function. Studies published in Frontiers in Pharmacology suggest that CBD may support neurogenesis and reduce neuroinflammation, potentially enhancing cognitive performance .

Scientific Research Supporting CBD Use for Chronic Fatigue

  1. Pain Management:
  2. Sleep Improvement:
  3. Anxiety and Depression:
  4. Anti-Inflammatory Effects:
  5. Neuroprotective Properties:

How to Use CBD for Chronic Fatigue

When considering CBD for chronic fatigue, it’s essential to start with a low dose and gradually increase it based on your body’s response. Here are some common forms of CBD and their usage:

  • CBD Oil/Tinctures: Place a few drops under your tongue for quick absorption.
  • CBD Capsules: Easy to consume with consistent dosing.
  • CBD Edibles: Gummies and other edibles offer a tasty way to take CBD.
  • Topicals: CBD-infused creams and balms can be applied directly to areas experiencing pain.

Final Thoughts

Chronic Fatigue Syndrome is a challenging condition with limited treatment options. While more research is needed to fully understand the benefits of CBD for CFS, current evidence suggests that it may offer relief from several symptoms associated with the condition, including pain, sleep disturbances, anxiety, and inflammation.


  1. Journal of Experimental Medicine: Link to study
  2. Permanente Journal: Link to study
  3. Neurotherapeutics Journal: Link to study
  4. European Journal of Pain: Link to study
  5. Frontiers in Pharmacology: Link to study

By exploring the potential benefits of CBD, you might find a new avenue for managing chronic fatigue and improving your quality of life.

About Bristol CBD:

Bristol CBD is the most trusted CBD brand in the UK with a trust score of 5.0 stars on both Google and Trustpilot. As well as CBD products, Bristol CBD also sell high-spec functional mushrooms including Lion’s Mane, Cordyceps, Shiitake, Chaga, Reishi and Turkey Tail.

We offer unparalleled customer service, support, guidance and advice and a 100% money back guarantee if you are not entirely satisfied with your product.

If you have any questions about how to buy or use CBD or medicinal mushroom products, please feel free to call us on 07706 031 935 at any time. We are always happy to share our experiences and help people to find the best solution for their own needs.

Please note that Bristol CBD staff are not qualified doctors or nurses and therefore we do not make any medical claims and cannot recommend CBD for specific ailments. Our articles are simply based on our own research and over 12 years experience of working with CBD and other supplements. We always encourage people to talk with their GPs, physicians or nurses before taking CBD products.

Share This

Save money on your CBD!

We know CBD can be expensive, so whenever we can, we send out discount coupons to our subscribers.

If you want to benefit from our hefty CBD discount offers, subscribe now below.
Follow us on